SCIENTIFIC POSTER
Functional characterization of healthy Alzheimer’s disease-related 3D neurospheres formed using human iPSC-derived glutamatergic neurons, GABAergic neurons, and astrocytes
Neural 3D organoids from human induced pluripotent stem cells (iPSC) are a rapidly developing technology with great potential for understanding brain development and neuronal diseases.
In this study, we chose to model Alzheimer’s Disease (AD) by incorporating allelic variants of the ApoE gene (2/2, 3/4, and 4/4) to create disease-specific “neurospheres”.
This assay platform shows promise for the evaluation of compound effects and early detection of neurotoxicity in vitro due to its ease of use, consistency across wells and assay plates, simplicity of data analysis, and ultimate biological relevance.
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FLIPR
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FLIPR Penta High-Throughput Cellular Screening System; FLIPR Calcium Assay Kits; ImageXpress Micro Confocal High-Content Imaging System
CMP
701Rn00000HeUonIAF
Title
Functional characterization of healthy and Alzheimer’s disease-related 3D neurospheres formed using human iPSC-derived glutamatergic neurons, GABAergic neurons, and astrocytes
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