Colorectal Cancer (CRC) Organoids

Patient-derived colorectal cancer organoids (CRC organoids or colorectal cancer PDOs) are multicellular mini replicas or “mini-guts” of the 3D tumor derived from patient tissues and grown in a research lab. They have been shown to retain in vivo characteristics of the original tumor and show drug responses that are similar to that of their derived organoids. This offers transformational possibilities for medical research and drug discovery.

Here we discuss the development, automation, and applications of patient-derived colorectal cancer organoids in high-throughput drug discovery. Our results show the superior potential of PDOs vs. other tissues in both precision medicine and high-throughput drug discovery applications when using automation with high-content imaging.

Learn more about Colorectal Cancer (CRC) Organoids