Single Cell Cloning

Single-Cell Cloning

Achieve superior monoclonal cell line development with our advanced single-cell cloning solutions

Single-Cell Cloning

Single-cell cloning is a laboratory technique used to isolate and grow individual cells to produce genetically uniform cell lines. This method ensures that each cell line originates from a single progenitor cell, which is crucial for applications requiring consistency and reproducibility, particularly in therapeutic protein production, drug development, and research studies. Traditional methods like limiting dilution cloning (LDC) are labor-intensive and inefficient, often requiring multiple rounds to achieve a high probability of clonality (PoC). Our advanced single-cell cloning solution including the DispenCell™ Single-Cell Dispenser and CloneSelect® Imager, streamlines the process by providing efficient, reliable methods for isolating and analyzing single cells, ultimately leading to high monoclonal colony yields and regulatory compliance. These tools are indispensable for industrial cell line development, enabling rapid, accurate, and efficient single-cell isolation and analysis.

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Mastering Monoclonality: The Next Generation of Single-Cell Dispensing and Imaging with the DispenCell and CloneSelect Imager

DispenCell Single-Cell Dispenser

High-precision single-cell dispensing system

The DispenCell™ Single-Cell Dispenser is designed to achieve high accuracy in single-cell isolation, significantly improving the efficiency of cell line development.

DispenCell Single-Cell Dispenser https://www.moleculardevices.com/products/clone-screening/single-cell-cloning/dispencell-single-cell-dispenser
  • High Probability of Clonality (PoC): Achieves a remarkable 98.4% PoC, ensuring robust and reliable cell line development.
  • Impedance-Based Technology: Precisely isolates single cells with minimal manual intervention, enhancing process accuracy.
  • Rapid Clonality Verification: Enables visual confirmation of monoclonality on Day 0, streamlining early-stage cloning.
  • Efficient Workflow Integration: Seamlessly integrates into automated workflows, reducing labor and resource demands.

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CloneSelect Imager

High-resolution imaging and analysis system for monoclonality assurance

The CloneSelect® Imager delivers high-resolution fluorescence imaging, and single-celll analysis to provide reliable evidence of monoclonality for regulatory compliance.

CloneSelect Imager https://main--moleculardevices--hlxsites.hlx.page/products/clone-screening/single-cell-cloning/cloneselect-imager
  • Automated Colony Screening: Screens colonies with high precision, supporting high-throughput cell line development.
  • Advanced Fluorescence Imaging: Captures detailed images to confirm clonality, improving data reliability.
  • Seamless Workflow Integration: Easily integrates with the DispenCell system for a comprehensive single-cell cloning solution.
  • Customizable Analysis Settings: Offers flexible imaging and analysis options to meet specific research requirements.

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Applications for Single cell cloning

Resources of Single cell cloning