Automate the entire cell culture process to improve workflows and make assays more reliable and reproducible.
The CellXpress.ai® Automated Cell Culture System is an AI-driven cell culture innovation hub that gives your team total control over demanding cell culture feeding and passaging schedules—eliminating time in the lab while maintaining a 24/7 schedule for growing and scaling multiple stem cell lines, spheroids, or organoids.
This revolutionary solution can give your lab the confidence in experimental outcomes to make key decisions sooner, achieve milestones faster, and get to clinic earlier—with lower attrition rates. All of it backed with the assurance of a full event log to confirm on-time feedings and critical task execution with complete digital microscopy records.

Automate your cell culture processes
Total control over demanding feeding and passaging schedules reduces hands-on time in the lab.

Improve your screening workflows
Around-the-clock operation maximizes productivity for growing and scaling multiple stem cell lines, spheroids, or organoids.

Develop reliable, reproducible assays
A machine learning-assisted solution standardizes the development process to deliver consistent, unbiased, and biologically relevant results at scale.
Features
Scale up complex cell culture workflows.
Actionable imaging and turnkey protocols for reliable media exchange, monitoring, and passaging. External devices and optional rocking incubator ensure the system is flexible enough to handle complex protocols and future-proof enough for protocols yet to come.
Evaluate & make decisions earlier.
Answer critical questions sooner easily identifying outliers at the well, plate, or experiment level to help detect variability sources. Save reagents by removing these plates or wells from downstream processing early in the drug discovery process.
Never miss a feeding event.
Give your cell culture technicians and scientists their weekends back. The CellXpress.ai system automates your cell culture, while image analysis workflows run 24/7 – even when your lab is closed.
Reduce human error.
Improve productivity and optimize hands-on time with image-based, deep-learning decision-making. Remove variability, maintain sterility, and increase confidence in success with automated cell handling.
Standardized protocols.
Reliable and consistent automation speeds the development process. Real-time feedback alerts users to milestones or events and generates automated tasks to resolve them.
Track the complete cell journey over time.
A unified software environment makes it easy to develop traceable and reproducible cell cultures specific to your desired assay endpoint.
Turn data into decisions.
Solve complex image analysis problems utilizing advanced artificial intelligence (AI) to transform images into results. User-friendly workflows help you get answers faster from 2D, 3D, and time lapse experiments.
Complex biology simplified
An approachable, truly hands-off automated solution built by scientists, for scientists.
The CellXpress.ai cell culture system was designed with the biologist’s point of view in mind. With the intuitive protocol wizard, users avoid complex scripting. Instead, you are able to build your workflows with an easy-to-use interface that follows the logical flow of the cell culture process.
The intuitive system dashboard gives you peace of mind to know that your culture run is operating as expected. A single software environment ensures that all the systems are operating at peak performance. No need to initialize individual instruments to ensure they are communicating with each other, simply walk up and use the system.
Error handling and reporting are integral to the system, so you can receive alerts should anything unexpected occur.


Machine learning-based decision-making allows users to distinguish between culture wells that are progressing as intended and those that aren’t. User alerts based on error or results-based conditions keep you advised of your cell culture status.
Relevant, reliable, and reproducible results
Access more biologically relevant models and ensure reproducibility—at scale
The CellXpress.ai cell culture system is a complete solution that standardizes the cell culture process—from maintenance, monitoring, and incubation, through imaging, analysis, and data processing—to deliver consistent, unbiased, and biologically-relevant results at scale.
- Unified software environment provides workflow repeatability through automation and applies imaging-guided AI decision-making to ensure cell culture feeding and passaging events happen at the right time.
- Powerful collaboration capabilities, leveraging built-in and custom protocols that can be easily executed, exported, and shared.
- System-ready robot integration support additional complex workflows—including centrifugation, confocal imaging, supernatant analysis, and calcium oscillation characterization.
The CellXpress.ai cell culture system is expandable and intended to support a variety of model system workflows in both 2D and 3D and in both matrix and matrix-free environments. Speak with one of our experts to discuss workflows that represent commonly used organoid culture protocols, including culture of 3D organoids in matrix domes or in low attachment plates, and iPSC culture protocols.
Latest Resources
Featured Applications
Applications of the CellXpress.ai Automated Cell Culture System
The CellXpress.ai® system is designed to enhance cell culture and assay protocols by addressing standardization, reproducibility, and scalability challenges. The system automates critical processes for various applications:
Specifications & Options of CellXpress.ai Automated Cell Culture System
CellXpress.ai cell culture system features and options
44 plate max – 2 rack capacity. Static racks
154 plate max – 7 rack capacity. Static racks
132 plate max static racks, 60 plate max rocking racks – 6-rack capacity
*CellXpress.ai cell culture system uses AutoQuant 2D Real Time Deconvolution