Organoids
Biologic research and disease modeling recapitulate complexity of real tissues
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that are designed to closely mimic the complex structure and functionality of human organs like the lung, liver or brain. Organoids are multi-cellular and demonstrate a high order of self-assembly to allow for an even better representation of complex in vivo cell responses and interactions, as compared to traditional 2D cell cultures.
There are three distinct definitions that differentiate an organoid:
- It's a 3D biological microtissue containing several types of cells
- Represents the complexity, organization and structure of a tissue
- And, resembles at least some aspect of a tissue’s functionality
