Dated: Jan 12, 2021
Publication Name: Journal of Immunological Methods
Citations : Measuring affinity constants of 1450 monoclonal antibodies to peptide targets with a microarray-based label-free assay platform
Monoclonal antibodies (mAbs) are major reagents for research and clinical diagnosis. For their inherently high specificities to intended antigen targets and thus low toxicity in general, they are pursued as one of the major classes of new drugs. Yet binding properties of most monoclonal antibodies are not well characterized in terms of affinity constants and how they vary with presentations and/or conformational isomers of antigens, buffer compositions, and temperature.
Contributors: J.P.Landry, Yaohuang Ke, Guo-Liang Yu, X.D.Zhu