Dated: Nov 14, 2019
Publication Name: Journal of Enzyme Inhibition and Medicinal Chemistry
Citations : Inhibition of SARS-Cov 3cl protease by flavonoids
There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, we applied a flavonoid library to systematically probe inhibitory compounds against SARS-CoV 3CLpro. Herbacetin, rhoifolin and pectolinarin were found to efficiently block the enzymatic activity of SARS-CoV 3CLpro.
Contributors: Seri Jo, Suwon Kim, Dong Hae Shin & Mi-Sun Kim