Water immersion technology and high-content imaging: A closer look

Three-dimensional (3D) cellular assays have emerged as a valuable tool in drug discovery and biological research, as they closely mimic in vivo environments and are shown to generate more physiologically relevant data than many 2D assays. With the increased utilization of 3D cultures for phenotypic screening and toxicity assessment, there is a growing need to optimize assay sensitivity, resolution, and throughput.