Human iPSC-derived 3D neural spheroids (Stemonix microBrain 3D)

To speed up the development of more effective and safer drugs, there is an increasing need for more complex, biologically relevant, and predictive cell-based assays for drug discovery and toxicology screening. Human iPSC-derived neural 3D co-cultures (StemoniX® microBrain® 3D platform) have been developed as a high-throughput screening platform that more closely resembles the constitution of native human cortical brain tissue. 3D neural spheroids contain a neural network enriched in synapses, creating a highly functional neuronal circuitry that displays spontaneous, synchronized, readily detectable calcium oscillations.

• Phenotypic characterization of neuroactive compound effects
• Complex event analysis for neurotoxic profiling of compound effects on human iPSC-derived neural spheroid 3D cultures
• Functional evaluation of neurotoxic and neuroactive compound effects in iPSC-derived 3D neural co-cultures
• Webinar: Implementing 3D neural spheroids in drug discovery
• Poster: Multiplexed automated assays for neurotoxicity evaluation using iPSC cell-derived neural 3D cell models