HTRF cAMP assays, Gαs-coupled receptors
Cyclic AMP (cAMP, cyclic adenosine 3’, 5’–monophosphate) is a key second messenger in GPCR signaling. The generation of cAMP is probably the most studied of signal transduction pathways and is involved in responses to sensory input, hormones, nerve transmission, and much more. Upon ligand binding to a GPCR, a conformational change occurs, activating the receptor and in turn activating a G protein. Further signal transduction depends on the type of G protein activated, but activation of Gαs leads to upregulation of cAMP by adenylate cyclase.
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