Hepatocytes
Stem cells differentiated into hepatocytes, or liver cells, can be used to predict liver toxicity by drug candidates. Drug-induced hepatotoxicity is an important cause for liver injury and acute liver failure. Thus, highly predictive assays for safety and efficacy testing are crucial for improving drug development. Here, we demonstrate the development of multi-parametric hepatotoxicity assays utilizing the ImageXpress Micro system. Each well or cell yields multiple compound-induced cellular responses, which are then analyzed using custom modules from MetaXpress® High-Content Image Acquisition & Analysis Software.