EarlyTox Cardiotoxicity Assay

Stem cell-derived human cardiomyocytes have phenotypic characteristics and electrophysiological profiles similar to those of native human cardiac cells. Cardiomyocytes in culture are able to form a beating syncytium, which behaves similarly to native cardiomyocytes. Oscillation of intracellular calcium levels occurring with synchronized contractions of the cells can be monitored using a calcium-sensitive dye, and treatment-induced changes in the pattern of oscillation can be monitored via changes in fluorescent signal over time.

Here is an application note you may find of interest:

• Multiparametric assays for cardiomyocytes on a single platform