Cardiomyocyte
Early prediction of drug-induced functional cardiotoxicity requires robust in vitro systems suitable for high-throughput screening. Readily-available iPSC-derived human cardiomyocytes may be used in conjunction with calcium-sensitive dyes, with beat rates and patterns monitored aschanges in intracellular calcium in response to both GPCRs and ion channels. These calcium peaks can be analyzed with our ScreenWorks Peak Pro 2 software which provides the investigator a suite of powerful tools for quantification of cardiomyocyte activity.
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