Assessment of compound-induced pro-arrhythmic effects in vitro
Using human iPSC-derived cardiomyocytes as an in vitro model, we evaluated the responses and concentration dependence to 28 drugs linked to low, intermediate, and high torsades de pointes (TdP) risk categories. The impact of various compounds on the beating rates and patterns of cardiomyocyte spontaneous activity was monitored by changes in intracellular Ca2+ oscillations measured by fast kinetic fluorescence with calcium-sensitive dyes on the FLIPR Penta system.