![Streamlining clonal selection and maintaining integrity](./media_18aa48d7cd483fa817912e9c7c71b5595831a8b69.jpeg?width=750&format=jpeg&optimize=medium)
APPLICATION NOTE
Leveraging microalgae metabolism to produce natural food dyes: an automated screening approach
![Leveraging microalgae metabolism to produce natural food dyes: an automated screening approach](./media_1a01cb487b215c771dfd75d6dedfeca1a73819a46.png?width=750&format=png&optimize=medium)
Streamlining clonal selection and maintaining integrity in bio-production through quantitative fluorescent screening and easy-to-use software
The food industry's interest in microalgae is increasing due to the growing demand for natural and sustainable food ingredients. Fermentalg® is utilizing microalgae metabolism to develop and screen multiple strains of G. sulphuraria that produce a natural blue pigment (BLUE ORIGINS®) with low pH and high temperature stability. Through automated colony screening using the QPix® 420 system, they were able to quickly identify desired clones with high concentrations of C-phycocyanin, expediting the scale-up of microalgae-based natural pigment production. This highlights the promising potential of high throughput automation for the future development of microalgal products.
Learn more about the systems behind the methods:
QPix 400 Series
Fully automate synthetic biology workflows for DNA assembly, antibody discovery and protein engineering
The QPix® 400 Series Microbial Colony Pickers combine intelligent image analysis with precise automation for fast and efficient screening of large libraries. With a variety of data tracking and assay tools, the QPix Software streamlines the control and management of complex and iterative processes.
- Automate several sample prep and plate handling processes such as transfer of bacterial liquid culture and plating on agar
- Streamline your workflow with scalable automation – pick up to 30,000 colonies per day
- Electronic data tracking for well-documented data control
- Sterile environment with customizable HEPA filtration options
Streamline your workflow when you pair the DispenCell with the CloneSelect Imager FL
The all-new CloneSelect Imager FL adds high contrast multichannel fluorescent technology in addition to the standard white light imaging that allows for accurate single-cell detection and proof of monoclonality at day 0. Identify and verify gene edits with comparative confluence assays.
Benefits
- Digitally record single-cell evidence and confluency for regulatory audits and submissions.
- Image cells non-invasively at multiple time points to monitor colony formation
- Screen using high-resolution white light imaging
- Deliver real-time results with on-the-fly analysis
- Automation and integration-ready
ClonePix Series
Automate antibody discovery and cell line development workflows
Screen more clones with the ClonePix® Series in less time with monoclonal verification on day zero, then screen and pick for highest producers in weeks, not months.
- Screen 10X more clones than limiting dilution
- Increase probability of identifying high-value clones
- Condense the workflow into a single solution
- Eliminate or recover unstable clones early
More Great Resources
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Blog
The role of CRISPR in microbiome engineering [Podcast]
The Role of CRISPR in Scientific Breakthroughs in Microbiome Engineering Clustered Regularly Interspaced Short Palindromic…
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Brochure
QPix XE Microbial Colony Picker
Although smaller than other colony pickers on the market, don’t let its size fool you – it doesn’t compromise on results.…
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Scientific Poster
Automated workflow for screening of CRISPR-edited cell lines. High throughput screening…
Gene editing allows us to manipulate DNA through deletions, additions, or other modifications using several tools. There are…