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Patch-Clamp Microelectrode Amplifier Comparison Chart

Axopatch 200B Amplifier MultiClamp 700B Amplifier Axoclamp 900A Amplifier
ApplicationsSingle-channel recording, whole-cell patch-clamp recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore studySingle-channel recording, whole-cell patch-clamp recording, intracelluar sharp electrode recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore studyWhole-cell current-clamp recording, intracelluar sharp electrode recording, extracellular recording, two-electrode voltage-clamp recording
Smart telegraphGain, filter, capacitanceGain, filter, capacitance, input/output scaling factors, recording mode - 2 channelsGain, filter, capacitance, input/output scaling factors, recording mode - 2 channels
Seal test
Holding potential range-/+ 1000 mV-/+ 1000 mV-/+ 200 mV for dSEVC and TEVC modes
Holding current range-/+ 200 nA-/+ 200 nAUp to -/+ 1/Ro (feedback resistor)
Output gain (mV/pA)0.5 to 5001.0 to 20001.0 to 2000
ModesI-Clamp, V-Clamp I-Clamp, V-ClampI-Clamp, DCC, HVIC, dSEVC, TEVC
Open circuit noise in 5kHz and 10 kHz0.06 pA rms, (5 kHz), 0.13 pA rms (10 kHz)0.15 pA rms, (5 kHz), 0.28 pA rms (10 kHz)N/A
True voltage clamp-resistor feedback for cSEVC for cSEVC for dSEVC
Capacitance Compensation (but not for whole-cell)
RMS Noise0.13 pA rms (10 kHz) increases to only 0.145 pA RMS when a patch-pipette holder is attached0.28 pA rms (10 kHz) at 50 GΩ to 3.0 pA rms (10 kHz) at 50 MΩ20 mV at 10 kHz
Automatic oscillation suppression
Automated mode-switching between current clamp and voltage clamp mode - Switch from I-clamp to dSEVC and TEVC mode
Slow current injection to maintain assigned potential
True current clamp-voltage follower
Simultaneous dual patch clamping recordings
Computer control: Holding level, current passing, filter option, multiple signal outputs, pipette offset, fast and whole cell capacitance compensation, series compensation, pipette neutralization, bridge balance
Conventional Interface with SoftPanel Controller with SoftPanel Controller